Drug Delivery: Principles and Engineering

This course introduces concepts of drug delivery to meet medical challenges. The course is designed to be modular, with each module focusing on the various aspects of drug delivery.INTENDED AUDIENCE : Anyone in bachelors having completed two yearPREREQUISITES : None. A course in biochemistry, molecular biology, anatomy is recommendedINDUSTRY SUPPORT : All pharmaceuticals, hospitals and biotechnology industries

Syllabus

Week 1: Pharmacokinetics: Bioavailability, Elimination, Therapeutic index Week 2: Prodrugs, Controlled release Week 3: Polymers: Synthesis, properties, characterization, crystallinity and amorphousness Week 4: Biopolymers: Natural and Synthetic, biocompatibility, Biodegradation, commonly used biopolymers Week 5: Polymer-Drug conjugates, PEGylation Week 6: Diffusion controlled systems, Ficks laws, Reservoir systems, Non-erodible matrix systems, Bio-erodible Systems Week 7: Hydrogels: Physical or chemical, pore-size calculation, in-situ crosslinking Week 8: Nano and Micro-particles: Dendrimers, Liposomes, Micelles Week 9: Metal and polymeric particles, effect of particle shape, charge and elasticity Week 10: Protein Adsorption and tissue engineering, Drug delivery in tissue engineering Week 11: Implant associated infections, Route specific delivery: Oral, Subcutaneous, Intramuscular, transdermal, inhalation, intravenous Week 12: Vaccines, Cancer vaccines, Cell and gene delivery, Smart responsive drug delivery, Targeted drug delivery, Nanotoxicology and market translation