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University of Malaya

Medical Image Registration with MATLAB: Techniques, Applications, and Clinical Implementation

University of Malaya via FutureLearn

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Overview

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Master image registration techniques for clinical impact

Medical image registration is the backbone of modern diagnostics, surgery planning, and therapeutic interventions. Learn the science and application of aligning medical images to support clinical decisions on this four-week course.

Whether you’re a biomedical engineer, clinician, or researcher, this course helps bridge the gap between theory and practice. You’ll explore core methods, software, and real-world case studies that are critical for effective implementation in clinical settings.

Discover the foundations of image registration in healthcare

Start by understanding the basics: what image registration is, why it matters in modern healthcare, and how it supports diagnostics and treatment.

You’ll explore different imaging modalities such as MRI, CT, PET, and ultrasound, and learn key principles of medical image analysis.

Implement core algorithms and techniques with MATLAB

Build hands-on skills in implementing image registration and alignment algorithms, including intensity-based, feature-based, and geometric transformations.

Using tools like MATLAB and 3D Slicer, you’ll apply techniques like rigid, affine, and deformable transformations and explore how to handle real-world implementation challenges.

Advance your skills with multimodal and 3D registration

Go deeper with advanced methods such as mutual information, gradient descent optimisation, and multimodal image alignment.

You’ll also explore validation metrics, file formats, coordinate systems, and the use of AI to improve accuracy and efficiency. Practical case studies in clinical imaging—spanning neurology, cardiology, oncology, and dentistry—bring theory to life.

This course is ideal for biomedical engineers, clinicians, radiologists, medical imaging specialists, and researchers looking to gain practical skills in medical image registration.

Syllabus

  • Introduction to Medical Image Registration, Formats and Visualization
    • Getting Started
    • Fundamentals of Medical Image Registration
    • Hands-on MATLAB Activities
    • Weekly Wrap Up
  • Intensity-Based Registration and Image Transformation
    • Intensity-Based Registration and Transformation Models in Medical Image Registration
    • Hands-on MATLAB Activities
    • Weekly wrap up
  • Understanding Similarity Measures in Medical Image Registration
    • Similarity Measures for Image Registration
    • Hands-on MATLAB Activities
    • Weekly Wrap Up
  • Optimization Techniques for Automated Image Registration
    • Optimization in Medical Image Registration
    • Hands-on MATLAB Activities
    • Weekly Wrap Up
  • Enhancing Optimization to Improve Accuracy and Efficiency of Image Registration
    • Optimizing Image Registration for Greater Accuracy and Efficiency
    • Hands-on MATLAB Activities
    • Weekly Wrap Up
  • Advanced Multimodal Registration Techniques and Built-In MATLAB Functions
    • Multimodal Registration
    • Part 1: Hands-on MATLAB Activities (Multimodal Registration)
    • Built-In MATLAB Functions
    • Part 2: Hands-on MATLAB Activities (Registration using Built-in Functions)
    • Wrapping Up: Key Takeaways and Future Directions
    • Course Wrap Up

Taught by

Yih Miin Liew

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