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Major advances have been achieved in the treatment of HIV infection but the number of new HIV-infections remains high worldwide, around 2.1 million in 2015 according to the latest UNAIDS report. Data strongly support the need to strengthen HIV prevention and to implement new effective prevention methods. Pre-exposure prophylaxis, PrEP has in several studies been proven to prevent sexual transmission of HIV infection. This course offers an introduction to the principles of PrEP and clinical considerations related to PrEP e.g. prescription, monitoring and adherence. In 2016 PrEP was approved by the European Commision and will in the years to come be implemented in Europe. This course provides information of how to engage community and key stakeholders for the implementation of PrEP and what impact PrEP could have on the HIV epidemic. The course also include examples of how PrEP was implemented in France and the UK.