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This course provides an introduction to health informatics, the discipline at the intersection of people, information, and technology in healthcare. Across four modules, it covers the transition from paper to electronic records and the distinctions among EMR, EHR, PHR, and CHR; how healthcare data is captured, organized, and stored, including database fundamentals, the components of the electronic health record, and the usability and workflow factors that determine whether systems succeed; the standards and terminologies that enable interoperability — HL7, FHIR, LOINC, SNOMED CT, ICD-10, and DICOM — along with health information exchange and information-blocking policy; and the application of informatics to clinical decision support and patient safety, telemedicine and telehealth, consumer and public health informatics, privacy and security, and artificial intelligence in healthcare.