Investigating Rapid Nuclear Mechanotransduction by Mapping Genome-wide Changes in Transcription

Watch a 53-minute lecture where Professor Jan Lammerding explores groundbreaking research on nuclear mechanotransduction and its impact on cellular functions. Discover how the nucleus responds to mechanical stimuli through genome-wide changes in transcription and chromatin accessibility, with findings revealing activation of mechanoresponsive genes within just 2 minutes of mechanical stretch - faster than previously known cytoplasmic signaling cascades. Learn about innovative research techniques like PRO-seq and ATAC-seq that demonstrate how promoter regions of mechanically-induced genes are primed for rapid activation, suggesting a novel direct role for the nucleus in mechanotransduction. Gain insights from Lammerding's extensive expertise in nuclear mechanobiology, supported by his distinguished career spanning Cornell University, Harvard Medical School, and MIT, with applications in muscular dystrophy, heart disease, and cancer research.