Center for Physical Genomics and Engineering Courses

Quantitative Super-Resolution Microscopy to Reveal Insights into Mesoscale Chromatin Organization

Explore how structured illumination microscopy (SIM) reveals insights into chromatin organization and cell cycle-dependent cohesion complex dynamics, with applications for understanding fundamental cellular processes.

• YouTube
• 1 hour 8 minutes
• Self-Paced
• Free Video

Technologies That Accelerate Cancer Biomarker and Therapeutic Target Discovery

Explore innovative epigenetic technologies developed by the Pattenden Lab for cancer research, focusing on chromatin accessibility patterns and screening methods for therapeutic targets in various cancer types.

• YouTube
• 58 minutes
• Self-Paced
• Free Video

Investigating Rapid Nuclear Mechanotransduction by Mapping Genome-wide Changes in Transcription

Explore groundbreaking research on nuclear mechanotransduction, examining how mechanical forces rapidly influence gene activation and chromatin accessibility through PRO-seq and ATAC-seq analysis.

• YouTube
• 53 minutes
• Self-Paced
• Free Video

Rapid Transcription Factor Degradation Reveals Mechanisms of Gene Regulation

Explore how CRISPR-mediated degron tagging enables rapid transcription factor degradation, revealing RUNX1's role in gene regulation, enhancer function, and myeloid development with implications for leukemia research.

• YouTube
• 59 minutes
• Self-Paced
• Free Video

Complex In Vitro Systems To Study Neurovascular Function In Health And Disease

Explore innovative in vitro neurovascular models that mimic brain function, enabling drug delivery research and screening for neurodegenerative diseases like Alzheimer's, presented by MIT Professor Roger Kamm.

• YouTube
• 1 hour 3 minutes
• Self-Paced
• Free Video

Mechanisms of Chromosome Folding and Gene Expression

Delve into chromosome folding mechanisms, exploring how DNA organization affects gene expression, replication, and cell division through phase separation and loop formation by molecular motors.

• YouTube
• 1 hour 14 minutes
• Self-Paced
• Free Video

The Physical Encoding of Transcriptional Memories in the Human Genome

Delve into groundbreaking research on genome organization, exploring how transcriptional memories are physically encoded through mass-fractal packing domains and their impact on cell development and aging.

• YouTube
• 1 hour 1 minute
• Self-Paced
• Free Video

Transcription Inhibition Suppresses Nuclear Blebbing and Rupture Independent of Nuclear Rigidity

Explore how transcription inhibition affects nuclear blebbing and rupture, examining mechanisms independent of nuclear rigidity through polymer simulations and force measurements.

• YouTube
• 59 minutes
• Self-Paced
• Free Video

Investigating Rapid Nuclear Mechanotransduction by Mapping Genome-wide Changes in Transcription

Explore groundbreaking research on nuclear mechanotransduction, examining how mechanical forces trigger rapid genomic changes and gene activation through advanced sequencing techniques and cellular observations.

• YouTube
• 1 hour 3 minutes
• Self-Paced
• Free Video

Role of Motors in Genome Folding

Explore the physics of chromosome folding, focusing on ATP-consuming motors' role in loop formation and mitotic structures. Learn about analytical models and their implications for genomic organization.

• YouTube
• 48 minutes
• Self-Paced
• Free Video

ATP-Dependent Remodeling of Hexasomes, Nucleosomes and Chromatin Condensates

Explore ATP-dependent chromatin remodeling, focusing on INO80's unique hexasome preference and its impact on higher-order chromatin organization. Gain insights into novel mechanisms regulating genome accessibility.

• YouTube
• 58 minutes
• Self-Paced
• Free Video

Epigenomic Landscape of Retrotransposon Expression in Senescence and Neurodegeneration

Explore the activation of retrotransposons in aging and neurodegeneration, focusing on LINE-1 elements' role in cellular senescence and potential implications for neurodegenerative diseases.

• YouTube
• 58 minutes
• Self-Paced
• Free Video

Many-to-Many Networks: Multifunctional Modules for Multicellularity

Explore how many-to-many protein networks function as versatile computational devices in multicellular organisms and their potential applications in synthetic biology for designing complex behaviors.

• YouTube
• 51 minutes
• Self-Paced
• Free Video

Mechanisms and Applications of DNA Methylation and Gene Silencing in Plants

Explore DNA methylation in plants, its role in gene silencing, and CRISPR-based tools for targeted methylation changes in research and crop improvement.

• YouTube
• 46 minutes
• Self-Paced
• Free Video

Capturing Biomolecular Interactions at Single-Molecule Level via ABEL Trap Fluorescence Spectroscopy

Explore cutting-edge ABEL Trap fluorescence spectroscopy for observing single-molecule biomolecular interactions, presented by Dr. Allison Squires of the University of Chicago.

• YouTube
• 29 minutes
• Self-Paced
• Free Video