Explore the evolution of application security in this 45-minute DEF CON 32 conference talk that delves into how emerging technologies like Mobile, IoT, Cloud, Blockchains, and GenAI have revolutionized traditional security approaches. Learn how AppSec has transformed from basic threat modeling and security scanning to sophisticated proactive prevention and real-time anomaly detection systems. Gain insights into maintaining robust security measures within 'everything as code' environments, with particular focus on configuration management and secret protection across both traditional and cloud infrastructure. Understand the challenges and solutions in securing increasingly complex technological ecosystems where traditional infrastructure boundaries continue to blur with cloud environments.