This course focuses on the core knowledge of pharmacokinetics, systematically explaining the internal turnover rules of drug absorption, distribution, metabolism, and excretion, and analyzing the meaning and calculation logic of various key parameters. The course combines practical scenarios such as new drug research and development, clinical drug administration, efficacy evaluation, and drug safety analysis to explain the practical application value of the discipline. At the same time, it reviews classic pharmacokinetic research models and basic analysis methods, building a complete knowledge framework. It helps students consolidate their professional theoretical foundation, master basic analysis skills, and adapt to professional learning in pharmacy, pharmaceutical engineering, biomedicine, and other related fields. It also lays a solid foundation for practical application in related positions.
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Syllabus
- Module 1: What is Pharmacokinetics
- Module 2: Drug Distribution
- Modules 3 & 4: Drug Metabolism and Excretion
- Module 5: Interpretation of Key Pharmacokinetic Parameters
- Module 6: Item-by-Item Study on the Technical Guidelines for Non‑Clinical Pharmacokinetic Studies of Drugs
- Module 7: Prospect of Pharmacokinetics
- Module 8: Pharmacokinetic Characteristics of Nano-formulations
- Experiment 1: Standard Operation and Calibration of Pipettes
- Experiment 2: In Vivo PK Study in Rats (Blood Sampling and Sample Processing)
- Experiment 3: Determination of Plasma Protein Binding Rate (Equilibrium Dialysis Method)
- Experiment 4: Metabolic Phenotyping Assay (CYP Enzyme Probe Substrate Method)
- Experiment 5: Liver Microsome Stability Test (Determination of In Vitro Metabolic Half-Life)
- Experiment 6: Whole Blood / Plasma Stability Test
- Experiment 7: Routine Maintenance of LC-MS/MS System
- final exam
Taught by
Guilin Medical University