Explore a thought-provoking 22-minute talk by Harsh Jain from the University of Minnesota - Duluth, presented at the Fields Institute on September 17, 2024. Delve into the intricacies of leveraging macroscopic preclinical data to simulate trials on truly heterogeneous populations in cancer research. Gain insights into mathematical modeling of cancer treatments, resistance, and optimization as part of the Thematic Program on Mathematical Oncology. Learn how this approach can potentially revolutionize the way clinical trials are designed and conducted, leading to more effective and personalized cancer treatments.