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Explore cutting-edge research in computational biomedicine, epigenetics, liquid biopsy, and alternative polyadenylation therapy through this 53-minute lecture by Wei Li at the Computational Genomics Summer Institute (CGSI) 2023. Delve into groundbreaking studies on alternative polyadenylation transcriptome-wide association, early detection of hepatocellular carcinoma using cell-free DNA, and the role of alternative polyadenylation in complex trait and disease heritability. Learn about innovative approaches such as Cellular Heterogeneity-Adjusted cLonal Methylation (CHALM) for improved gene expression prediction and a cell-free DNA methylation fingerprint for early detection of gastrointestinal cancers. Gain insights into the latest advancements in computational genomics and their applications in understanding and treating various diseases, including brain disorders, liver cancer, and gastrointestinal cancers.
