Explore groundbreaking cardiovascular research in this Yale Cardiovascular Medicine Grand Rounds lecture examining how mouse models advance our understanding of disease mechanisms, with specific focus on cavernous malformation and COVID-19 pathology. Delve into experimental methodologies and key findings that bridge laboratory research with clinical applications, offering valuable insights into these two distinct but significant medical conditions. Learn how animal models contribute to unraveling complex disease processes and potential therapeutic interventions, presented through the lens of cutting-edge cardiovascular medicine research.