Explore gRPC, a modern open-source Remote Procedure Call (RPC) framework revolutionizing distributed systems communication, in this 14-minute conference talk by Jung-Yu (Gina) Yeh, a gRPC maintainer. Discover the core principles, benefits, and practical applications of gRPC while learning how it leverages HTTP/2 for efficient bi-directional streaming and Protocol Buffers for language-agnostic, strongly-typed data serialization. Understand why gRPC serves as a powerful solution for high-performance, low-latency communication in microservices, real-time applications, and polyglot environments, gaining insights directly from a framework maintainer's perspective.