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Explore advanced statistical methods for analyzing two-phase treatment scenarios with patient noncompliance in this 58-minute conference talk from ICBS2025. Learn how to identify and estimate cumulative average treatment effects when dealing with complex real-world situations where patients may not fully adhere to prescribed treatment protocols. Discover the application of multisite instrumental variables as a powerful analytical tool for addressing noncompliance issues across different research sites or populations. Gain insights into sophisticated causal inference techniques that can help researchers and practitioners better understand treatment effectiveness in the presence of adherence challenges, making this presentation valuable for biostatisticians, epidemiologists, and clinical researchers working with longitudinal treatment data.