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Explore the latest research on RNA modifications in pancreatic islet β-cells during glucose stimulation in this 43-minute seminar by Logan Mulroney from the National Human Genome Research Institute. Delve into the investigation of N-6-methyladenosine (m6A) and its potential role in Type 2 diabetes (T2D), as well as the application of direct RNA nanopore sequencing (dRNA-seq) to detect multiple RNA modifications simultaneously. Learn about the study's findings, including the identification of 2643 m6A and 1522 pseudouridine RNA modifications that significantly changed after glucose stimulation, with a focus on transcripts associated with T2D. Gain insights into the molecular mechanisms driving T2D in pancreatic islet β-cells and understand the implications for future large-scale studies in this field.
