Learn about groundbreaking research in cardiovascular medicine through this comprehensive lecture delivered by Dr. Deepak Srivastava, President of the Gladstone Institutes and Director of the Roddenberry Stem Cell Center. Explore the complex interactions between myeloid cells and fibroblasts during heart failure, understand the transcriptional disruptions caused by Trisomy 21 in atrioventricular septal defects, and examine how Notch haploinsufficiency leads to calcific aortic valve disease. Drawing from his extensive background as a Professor of Pediatrics and Biochemistry & Biophysics at UCSF Medical Center, Dr. Srivastava shares insights from his distinguished career spanning training at UCSF and Harvard Medical School's Children's Hospital. Gain valuable knowledge about cellular reprogramming mechanisms and their role in various cardiovascular conditions during this hour-long presentation.