This conference talk explores how to effectively architect Istio for large-scale deployments, presented by Lior Lieberman from Google and Erik Parienty from Riskified. Dive into the challenges of managing Istio at scale, from handling complex routing configurations to balancing developer autonomy with production stability. Learn from Riskified's infrastructure team's journey as they share their experiences implementing self-service traffic management, cost efficiency measures, and topology-aware routing in a large service mesh environment. Discover practical strategies, common pitfalls, and valuable lessons that can help navigate the complexities of scaling Istio deployments. Gain actionable insights whether you're currently scaling your service mesh or looking to streamline Istio management in your organization.