Active Transcription Controls the Kinetics of Nucleolar Assembly in Early C. elegans Embryos

Explore how active transcription regulates the formation dynamics of nucleoli in early C. elegans embryos through this 26-minute conference talk. Delve into the mechanisms by which living cells coordinate molecular activities in space and time, focusing on the assembly of membrane-less compartments called biomolecular condensates. Learn about the robust cellular processes that concentrate specific molecules into these condensates, which play crucial roles in gene expression, signal transduction, and neurotransmission. Examine the diverse properties of condensates including their lifetimes, sizes, mechanochemical characteristics, and architectures. Discover current research addressing the fundamental question of how the emergent physical properties of biomolecular condensates mediate their biological functions. Gain insights into theoretical frameworks, simulation approaches, and experimental methods used to characterize these cellular structures and understand the physicochemical principles that shape their formation and behavior.