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Explore laboratory techniques for investigating monoclonal gammopathy and protein disorders in this 43-minute lecture. Learn about serum protein electrophoresis, a powerful tool that separates proteins based on physical properties, and how immunofixation identifies monoclonal proteins (M-proteins) resulting from abnormal plasma cell proliferation. Discover the increased sensitivity of serum free light chain (SFLC) testing methods compared to traditional techniques, and understand how SFLC analysis can identify patients with light chain multiple myeloma, amyloidosis, and nonsecretory multiple myeloma that may be missed by standard protein electrophoresis.
