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Southwest University

高级分子生物学

Southwest University via XuetangX

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高级分子生物学是生物学一级学科研究生专业必修课，以遗传信息的传递、表达和调控作为课程核心，系统讲解基因和基因组的结构和功能、DNA复制和重组、RNA转录和加工、蛋白质翻译和修饰以及在不同的分子水平上对基因表达的调控机制。通过本课程的学习，使学生能深入理解分子生物学的基本原理、技术方法和前沿知识，掌握必要的专业词汇，提高学生文献阅读、科研设计、跟踪最新进展和自我学习的能力，培养创新思维、为未来的学术研究和职业发展打下基础。



Syllabus

  • 第一章Chapter 1 Genes Are DNA and Encode RNAs and Polypeptides
    • 第二章Chapter 2 Methods in Molecular Biology and Genetic Engineering
      • 第三章Chapter 3 The Interrupted Gene
        • 第四章Chapter 4 The Content of the Genome
          • 第五章Chapter 5 Replication Is Connected to the Cell Cycle
            • 5.1 The bacterial mechanism
            • 5.2 The eukaryotic mechanism
          • 第六章Chapter 6 The Replicon: Initiation of Replication
            • 6.1 Basic principles of DNA replication
            • 6.2 Initiation of prokaryotic replication
            • 6.3 Initiation of eukaryotic replication
          • 第七章Chapter 7 DNA Replication
            • 7.1 DNA polymerase
            • 7.2 Elongation of DNA replication
            • 7.3 Termination of DNA replication
          • 第八章Chapter 8 Extrachromosomal Replicons
            • 8.1 Rolling circle replication
            • 8.2 Displacement loop replication
            • 8.3 Partition system of plasmid
          • 第九章Chapter 9 Homologous and Site-Specific Recombination
            • 9.1 Homologous Recombination
            • 9.2 Proteins involved in Homologous Recombination
            • 9.3 Site-Specific Recombination
          • 第十章Chapter 10 Repair Systems
            • 10.1 Direct Repair and Excision Repair
            • 10.2 Recombination Repair and Nonhomologous End Joining
            • 10.3 Error-prone Repair System_1
          • 第十一章Chapter 11 Transposable Elements and Retroviruses
            • 11.1 Transposons
            • 11.2 Retroviruses
          • 第十二章Chapter 12 Prokaryotic Transcription
            • 12.1 Bacterial RNA Polymerase
            • 12.2 Initiation of Transcription
            • 12.3 Elongation and Termination of Transcription
            • 12.4 Regulation of Transcription
          • 第十三章Chapter 13 Eukaryotic Transcription
            • 13.1 Introduction of Eukaryotic Transcription
            • 13.2 Eukaryotic RNA Polymerase and Transcription Factors
            • 13.3 Eukaryotic Transcription
            • 13.4 Regulation of Eukaryotic Transcription
          • 第十四章Chapter 14 RNA Splicing and Processing
            • 14.1 RNA Splicing and Processing
            • 14.2 The 5′ End of Eukaryotic mRNA Is Capped
            • 14.3 Splicing of Introns
            • 14.4 Splice Sites Are Read in Pairs
            • 14.5 Pre-mRNA Splicing Proceeds Through a Lariat
          • 第十五章Chapter 15 mRNA Stability and Localization
            • 15.1 Introduction
            • 15.2 Messenger RNAs Are Unstable Molecules
            • 15.3 Eukaryotic mRNAs Exist in the Form of mRNPs from Their Birth to Their Death
          • 第十六章Chapter 16 Catalytic RNA
            • 16.1 Catalytic Activity of Group I Introns
            • 16.2 Catalytic Activity of Group II Introns
            • 16.3 RNA Editing and Protein Splicing
          • 第十七章Chapter 17 Translation
            • 17.1 Introduction
            • 17.2 Translation Occurs by Initiation, Elongation, and Termination
            • 17.3 Special Mechanisms Control the Accuracy of Translation
          • 第十八章Chapter 18 Using the Genetic Code
            • 18.1 Introduction
            • 18.2 Aminoacyl-tRNA
            • 18.3 Suppressor tRNA
            • 18.4 Frameshifting and Translational Bypassing
          • 第十九章Chapter 19 The Operon
            • 19.1 Structural Gene Clusters Are Coordinately Controlled
            • 19.2 The lac Operon Is Negative Inducible
          • 第二十章Chapter 20 Phage Strategies
            • 20.1 Introduction
            • 20.2 Lytic Development Is Divided into Two Periods
            • 20.3 Lytic Development Is Controlled by a Cascade
            • 20.4 Two Types of Regulatory Events Control the Lytic Cascade
          • 第二十一章Chapter 21 Eukaryotic Transcription Regulation
            • 21.1 Introduction
            • 21.2 How Is a Gene Turned On-
          • 第二十二章Chapter 22 Epigenetics I
            • 22.1 Introduction
            • 22.2 Heterochromatin Propagates from a Nucleation Event
            • 22.3 Prions Show Unusual Inheritance
          • 第二十三章Chapter 23 Epigenetics II
            • 23.1 X Chromosome Inactivation
            • 23.2 DNA Methylation Is Responsible for Imprinting
          • 第二十四章Chapter 24 Noncoding RNA
            • 第二十五章Chapter 25 Regulatory RNA
              • 期末考试

                Taught by

                Yi Wang, Xin Wang, and Fei Wang

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