Regeneration Biology

Week 1:1. Basics of regeneration: basics and types2. Regeneration, Wound healing and Scar formation in different regenerative capacity3. Regeneration: in normal life and implications4. Tissue regeneration: mammalian context5. Liver regeneration: Signaling events
Week 2:6. Liver regeneration: mechanistic insights 7. Regeneration: lessons from animal model Hydra 8. Mechanisms of regeneration in Hydra 9. Asexual Reproduction- Fragmentation. Morphallaxis, Epimorphosis, lessons from Hydra10. Mechanisms of regeneration in Planaria
Week 3:
11. Planaria regeneration-polarity and gradient in regeneration 12. Planaria regeneration: Neoblasts and organ formation 13. Planaria regeneration: Species type and enviornment 14. Position control genes and regeneration 15. Progenitor targeting and ectopic organs
Week 4:
16. Tissue dedifferentiation, cellular reprograming into blastema Cellular types in regeneration. Neural crest cells in vertebrates 17. Totipotency, pluripotency, multipotency and unipotency, in regeneration context18. Adult stem cells: Natural and induced and their roles in regeneration-zebrafish 19. Common cellular events during regeneration, embryonic development, and cancer20. Epithelial to mesenchymal transition (EMT) and mesenchymal to epithelial transition (MET) in regeneration
Week 5:
21. Organ regeneration: Basics with examples 22. Zebrafish fin regeneration-in a brief 23. Zebrafish heart regeneration-in a brief 24. Zebrafish retina regeneration-in a brief 25. Spinal cord and brain regeneration-Conclusive mechanisms of regeneration
Week 6:
26. Cellular, Molecular and Genetic factors involved in retina regeneration 27. Detailed mechanisms of fin regeneration 28. Retina regeneration-importance of Shh signaling Roles of epigenetic factors and their involvement in regeneration 29. Importance of regeneration associated gene induction events-Transcription activators and repressors 30. Roles of different cellular signaling in regeneration: Examples- Wnt signaling
Week 7:
31. Different cellular signaling during regeneration-Overview 32. Different cellular signaling during regeneration. Examples- Jak-STAT and Fgf signaling 33. Different cellular signaling during regeneration -Egf, and Hippo signaling 34. Roles of Delta-Notch signaling during regeneration 35. Tgf-beta signaling during regeneration
Week 8:
36. Organ regeneration: An overview 37. Accessory limb model of regeneration: lessons from Axolotl and newt 38. Nerve-dependent regeneration-Axolotl and Newt 39. Roles of Histone deacetylases in regeneration of vertebrates like fishes and amphibians 40. Dynamics of immune system in organ regeneration regeneration
Week 9:
41. Extracellular matrix and its roles in tissue regeneration 42. Induced pluripotency and roles if iPFs during tissue Hox genes and homeotic transformation 43. Animal cloning: implications in regeneration 44. Embryonic stem cells, cord blood stem cells and adult stem cells 45. Ethics of stem cell research in regeneration studies, regenerative medicine and biotechnology
Week 10:
46. Tissue engineering and-Why and how? 47. History of tissue engineering 48. Different steps in tissue engineering 49. Different aspects of organ culture 50. Major challenges in tissue engineering in practice
Week 11:
51. Tissue 3D printing and organ culture 52. Importance of scaffolds in tissue engineering 53. Stem cells for tissue engineering-Use of CRISPR-Cas9 for genome targeting 54. Types of adult stem cells and trans-differentiation for tissue engineering 55. Influence of niches and scaffolds on stem cells: An organ culture perspective 56. The basics of regeneration put into practice in vitro.
Week 12:57. Adhesion, migration and aggregation of stem cells 58. Artificial, liver, kidney and urinary bladder for transplantation in patients 59. Limbal stem cells and artificial cornea 60. Xenotransplantation vs organ culture in practice 61. Future implications of regeneration in mammals 62. Future implications of Organ culture in patient care