Classics in Total Synthesis - I

About the course:Some of the classical total synthesis of natural and unnatural products reported between 1950-2000 will be discussed in details. This course will be ideal for 2nd year MSc students and 1st year Ph.D students. This course will be followed by part-II where some important total synthesis of natural products disclosed between 2001 to-date will be discussed.PRE-REQUISITES: BSc and MSc (1st year)INTENDED AUDIENCE: Chemistry Masters students/Chemistry PhD students.INDUSTRY SUPPORT: Most of the pharmaceutical companies.

Syllabus

Week 1: General Introduction to Total Synthesis & Total Synthesis of Cubane Week 2:Total Synthesis of Cubane Week 3:Total Syntheses of Endiandric Acids and Prostaglandins Week 4:Total Synthesis of triquinanes Week 5:Total Synthesis of triquinanes Week 6:Total Syntheses of Longifolene and Penicillin Week 7:Total Synthesis of steroids (Estrone, Progesterone, Cholesterol) Week 8:Total Syntheses of perhydrohistrionicotoxin, methylhomosecodaphnyllane, Week 9:Total Syntheses of Quinine, Yohimbine and Reserpine Week 10:Total Syntheses of Strychnine and Morphine Week 11:Total Synthesis of Taxol Week 12:Total Syntheses of Epothilones and Eleutherobin